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Indole alkaloid biosynthesis

State Icon Reaction EC-Number Confidence maximal confidence score from EnzymeDetector
vindoline + Catharanthine <=> 3'',4''-Anhydrovinblastine not assigned
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psilocybin <=> psilocin not assigned
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Dialdehyde + H+ <=> 4,21-Dehydrocorynantheine_aldehyde + H2O not assigned
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S-adenosyl-L-methionine + norajmaline <=> ajmaline + S-adenosyl-L-homocysteine + H+ 2.1.1.M48
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Geissoschizine + reduced_flavodoxin + O2 <=> polyneuridine_aldehyde + flavin + 2 H2O 1.14.14
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fumigaclavine_A + dimethylallyl_diphosphate <=> fumigaclavine_C + diphosphate 2.5.1.100 fumigaclavine A dimethylallyltransferase
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S-adenosyl-L-methionine + 17-O-acetylnorajmaline <=> 17-O-acetylajmaline + S-adenosyl-L-homocysteine + H+ 2.1.1
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Stemmadenine <=> Catharanthine not assigned
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tabersonine <=> Lochnerinine not assigned
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dimethylallyl_diphosphate + L-tryptophan <=> 4-dimethylallyl-L-tryptophan + diphosphate 2.5.1.34 4-dimethylallyltryptophan synthase
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4-hydroxy-L-tryptophan + H+ <=> 4-hydroxytryptamine + CO2 4.1.1.105 L-tryptophan decarboxylase
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gardneral + acetyl-CoA <=> vinorine + CoA 2.3.1.160 vinorine synthase
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S-adenosyl-L-methionine + 4-hydroxy-N-methyltryptamine_4-phosphate <=> S-adenosyl-L-homocysteine + psilocybin + H+ 2.1.1.345 psilocybin synthase
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S-adenosyl-L-methionine + 4-hydroxytryptamine_4-phosphate <=> S-adenosyl-L-homocysteine + 4-hydroxy-N-methyltryptamine_4-phosphate + H+ 2.1.1.345 psilocybin synthase
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ATP + 4-hydroxytryptamine <=> ADP + 4-hydroxytryptamine_4-phosphate + H+ 2.7.1.222 4-hydroxytryptamine kinase
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4,21-Dehydrogeissoschizine <=> 19-epi-Cathenamine not assigned
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deacetylvindoline + acetyl-CoA <=> vindoline + CoA 2.3.1.107 deacetylvindoline O-acetyltransferase
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(3R)-3-hydroxy-2,3-dihydrotabersonine + acceptor <=> (3R)-3-hydroxy-1,2-didehydro-2,3-dihydrotabersonine + reduced_acceptor 1.1.99.41 3-hydroxy-1,2-didehydro-2,3-dihydrotabersonine reductase
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UDP-glucose + Vomilenine <=> H+ + Raucaffricine + UDP 2.4.1.219 vomilenine glucosyltransferase
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vinblastine <=> vincristine not assigned
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chanoclavine-I + NAD+ <=> chanoclavine-I_aldehyde + NADH + H+ 1.1.1.332 chanoclavine-I dehydrogenase
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fumigaclavine_B + acetyl-CoA <=> fumigaclavine_A + CoA 2.3.1.205 fumigaclavine B O-acetyltransferase
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strictosidine_aglycone <=> Dialdehyde not assigned
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cathenamine + NADPH + H+ <=> Ajmalicine + NADP+ not assigned
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agroclavine + NADP+ <=> 6,8-dimethyl-6,7,8,9-tetradehydroergoline + NADPH + H+ 1.5.1.46 agroclavine dehydrogenase
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festuclavine <=> fumigaclavine_B not assigned
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cathenamine + NADPH + H+ <=> Tetrahydroalstonine + NADP+ not assigned
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Ajmalicine + reduced_flavodoxin + O2 <=> serpentine + flavin + 2 H2O + 2 H+ 1.14.14
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Raucaffricine + H2O <=> Vomilenine + D-glucose 3.2.1.125 raucaffricine beta-glucosidase
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4,21-Dehydrogeissoschizine <=> Stemmadenine not assigned
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S-adenosyl-L-methionine + 16-methoxy-2,3-dihydro-3-hydroxytabersonine <=> S-adenosyl-L-homocysteine + deacetoxyvindoline + H+ 2.1.1.99 3-hydroxy-16-methoxy-2,3-dihydrotabersonine N-methyltransferase
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S-adenosyl-L-methionine + 16-hydroxytabersonine <=> H+ + S-adenosyl-L-homocysteine + 16-methoxytabersonine 2.1.1.94 tabersonine 16-O-methyltransferase
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Stemmadenine <=> tabersonine not assigned
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1,2-dihydrovomilenine + NADP+ <=> Vomilenine + NADPH + H+ 1.5.1.32 vomilenine reductase
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H2O + polyneuridine_aldehyde <=> methanol + CO2 + gardneral 3.1.1.78 polyneuridine-aldehyde esterase
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16-methoxy-2,3-dihydro-3-hydroxytabersonine + acceptor <=> (3R)-3-hydroxy-16-methoxy-1,2-didehydro-2,3-dihydrotabersonine + reduced_acceptor 1.1.99.41 3-hydroxy-1,2-didehydro-2,3-dihydrotabersonine reductase
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tabersonine + reduced_flavodoxin + O2 <=> (3R)-3-hydroxy-1,2-didehydro-2,3-dihydrotabersonine + flavin + H2O 1.14.14.50 tabersonine 3-oxygenase
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dihydrochanoclavine-I_aldehyde <=> 6,8-dimethyl-6,7-didehydroergoline + H2O not assigned
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strictosidine + H2O <=> strictosidine_aglycone + D-glucose 3.2.1.105 3alpha(S)-strictosidine beta-glucosidase
3.2.1.125 raucaffricine beta-glucosidase
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4-dimethylallyl-L-abrine <=> chanoclavine-I not assigned
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10-deoxysarpagine + NADP+ <=> gardneral + NADPH + H+ 1.1.1.273 vellosimine dehydrogenase
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tabersonine <=> 19-Hydroxytabersonine not assigned
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cathenamine <=> 4,21-Dehydrogeissoschizine not assigned
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alpha-3,4''-anhydrovinblastine + H2O <=> vinblastine not assigned
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tabersonine <=> Minovincinine not assigned
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19-Hydroxytabersonine <=> Horhammericine not assigned
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tryptamine + secologanin <=> strictosidine + H2O 4.3.3.2 strictosidine synthase
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17-O-acetylnorajmaline + NADP+ <=> 1,2-dihydrovomilenine + NADPH + H+ 1.3.1.73 1,2-dihydrovomilenine reductase
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chanoclavine-I_aldehyde <=> 6,8-dimethyl-6,7,8,9-tetradehydroergoline + H2O not assigned
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17-O-acetylajmaline + H2O <=> ajmaline + acetate + H+ 3.1.1.80 acetylajmaline esterase
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H+ + L-tryptophan <=> CO2 + tryptamine 4.1.1.105 L-tryptophan decarboxylase
4.1.1.28 aromatic-L-amino-acid decarboxylase
4.1.1.53 phenylalanine decarboxylase
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–
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Tetrahydroalstonine + reduced_flavodoxin + O2 <=> Alstonine + flavin + 2 H2O + 2 H+ 1.14.14
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gardneral <=> gardneral not assigned
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10-deoxysarpagine + reduced_flavodoxin + O2 <=> sarpagine + flavin + H2O 1.14.14.136 deoxysarpagine hydroxylase
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ATP + psilocin <=> ADP + psilocybin + H+ 2.7.1.222 4-hydroxytryptamine kinase
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Minovincinine + acetyl-CoA <=> Echitovenine + CoA not assigned
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vinorine + reduced_flavodoxin + O2 <=> Vomilenine + flavin + H2O 1.14.14.104 vinorine hydroxylase
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tabersonine + reduced_flavodoxin + O2 <=> 16-hydroxytabersonine + flavin + H2O 1.14.14.103 tabersonine 16-hydroxylase
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Lochnericine <=> Horhammericine not assigned
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19-epi-Cathenamine + NADPH + H+ <=> 19-epi-Ajmalicine + NADP+ not assigned
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tabersonine + NADPH + H+ + O2 <=> Lochnericine + NADP+ + H2O not assigned
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16-methoxytabersonine + reduced_flavodoxin + O2 <=> (3R)-3-hydroxy-16-methoxy-1,2-didehydro-2,3-dihydrotabersonine + flavin + H2O 1.14.14.50 tabersonine 3-oxygenase
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Geissoschizine + NADP+ <=> 4,21-Dehydrogeissoschizine + NADPH 1.3.1.36 geissoschizine dehydrogenase
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tabersonine <=> Horhammericine not assigned
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4,21-Dehydrocorynantheine_aldehyde <=> 4,21-Dehydrogeissoschizine not assigned
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S-adenosyl-L-methionine + 4-dimethylallyl-L-tryptophan <=> 4-dimethylallyl-L-abrine + S-adenosyl-L-homocysteine + H+ 2.1.1.261 4-dimethylallyltryptophan N-methyltransferase
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tryptamine + reduced_acceptor + O2 <=> 4-hydroxytryptamine + acceptor + H2O 1.14.99.59 tryptamine 4-monooxygenase
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dihydrochanoclavine-I_aldehyde + NADP+ <=> chanoclavine-I_aldehyde + NADPH + H+ 1.3.1.100 chanoclavine-I aldehyde reductase
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festuclavine + NAD+ <=> 6,8-dimethyl-6,7-didehydroergoline + NADH + H+ 1.5.1.44 festuclavine dehydrogenase
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17-O-acetylnorajmaline + H2O <=> norajmaline + acetate + H+ 3.1.1.80 acetylajmaline esterase
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deacetoxyvindoline + 2-oxoglutarate + O2 <=> deacetylvindoline + succinate + CO2 1.14.11.20 deacetoxyvindoline 4-hydroxylase
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